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  4. Faecal Calprotectin Test: High vs. Low Levels Explained

Faecal Calprotectin Test: High vs. Low Levels Explained

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A faecal calprotectin test measures the level of calprotectin, a protein released by white blood cells, in your stool. High levels typically indicate inflammation in the intestines, which can be a sign of conditions like Crohn’s disease or ulcerative colitis. Low levels suggest that intestinal inflammation is unlikely, making conditions such as irritable bowel syndrome (IBS) more probable. Understanding whether calprotectin levels are high or low helps doctors distinguish between inflammatory bowel diseases (IBD) and non-inflammatory conditions, guiding appropriate treatment plans.

Faecal calprotectin is an important marker used to assess intestinal inflammation. Here’s what high and low levels mean for your health:

  • High Faecal Calprotectin Levels:
    • Significance: High levels typically point to the presence of inflammation in the intestines.
    • Associated Conditions: Conditions such as Crohn’s disease, ulcerative colitis, and infections like bacterial gastroenteritis can cause elevated calprotectin.
    • Symptoms to Watch For: Symptoms like chronic diarrhea, abdominal pain, and unexplained weight loss often accompany elevated levels.
    • Treatment: Depending on the underlying condition, treatment may include anti-inflammatory medications, immunosuppressants, or antibiotics to manage infections.
  • Low Faecal Calprotectin Levels:
    • Significance: Low levels generally indicate a lack of inflammation, suggesting non-inflammatory conditions.
    • Associated Conditions: Low calprotectin levels are often found in patients with irritable bowel syndrome (IBS), which does not involve intestinal inflammation.
    • Symptoms: Bloating, abdominal discomfort, and changes in bowel habits (without inflammation) are common in IBS.
    • Treatment: IBS is typically managed with dietary changes, stress management, and sometimes medications to control symptoms.
  • When to Seek Medical Advice: If you experience persistent gastrointestinal symptoms, it’s important to consult a healthcare provider. Calprotectin levels help differentiate between IBD and less serious conditions like IBS, ensuring appropriate treatment.

Recommended Tests:

  1. Complete Blood Count (CBC):
    A CBC can help assess overall health and detect signs of inflammation or infection, complementing the faecal calprotectin test.
    Complete Blood Count (CBC)
  2. Erythrocyte Sedimentation Rate (ESR):
    ESR is another marker of inflammation that can provide additional information about inflammatory conditions.
    Erythrocyte Sedimentation Rate (ESR)

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