High levels of serum folate, or vitamin B9, detected through a blood test can be indicative of several health conditions or excessive intake of folic acid. While folate is crucial for many bodily functions, such as DNA synthesis and red blood cell production, elevated levels may raise concerns.
- Causes of High Serum Folate:
- Excessive Supplementation: Overconsumption of folic acid supplements can cause high serum folate levels. Folate from dietary sources is less likely to lead to elevated levels.
- Vitamin B12 Deficiency: One key concern is that high folate can mask the symptoms of vitamin B12 deficiency. This can lead to unnoticed and untreated neurological damage.
- Liver Disease: Liver conditions, such as cirrhosis or hepatitis, may alter folate metabolism and result in high levels.
- Cancer: Certain cancers, particularly those affecting blood or the gastrointestinal system, can elevate folate levels as a side effect of abnormal cell proliferation.
- Symptoms of Related Conditions:
- Neurological symptoms (e.g., tingling, memory loss) related to hidden vitamin B12 deficiency.
- Fatigue and weakness if associated with underlying conditions like liver disease or cancer.
- Treatment Options:
- Adjusting Supplement Intake: If over-supplementation is the cause, reducing folic acid intake is the first step.
- Addressing Vitamin B12 Deficiency: Vitamin B12 supplements or dietary changes can correct the deficiency while managing folate levels.
- Managing Underlying Conditions: Treating liver disease or cancer may involve medication, lifestyle changes, or targeted therapies.
Recommended Tests:
- Active B12 Test
To assess for potential vitamin B12 deficiency, especially when high folate levels are present.
Active B12 Test - Liver Function Test (LFT)
To check for liver disease that may cause abnormal folate metabolism.
Liver Function Test
